MR tractography uses data sets from diffusion weighted MR images to show white matter organization and orientation of white matter fibers in the brain (the “wires” of the brain). Tractography is helpful for preoperative planning and understanding seizure propagation in epilepsy and other brain disorders. In the future, it may also be able to play a role in evaluating how the brain as a whole is connected, and how such connectivity is altered in certain disease states. Funded by a number of NIH grants, researchers at Boston Children’s Hospital have developed unique MR tractography technologies via ground-breaking novel acquisition and reconstruction techniques.